Services - Synthos CARE

SERVICES

Synthos CARE provides a wide range of tests, assays, and analytical services for pharmaceutical products, cosmetics, dietary supplements, and medical devices. We also supply tests, starting materials and intermediate products. Synthos CARE supplies a wide range of equipment, including HPLC (with UV-VIS, DAD, fluorescent, ELSD and M detector), particle size and zeta-potential measurement devices, viscosity meters, freeze-dryers and spectrometers).
 

Tests and services provided:

  • Testing of active substances in cosmetics, dietary supplements, and medicinal products (vitamins A, E, C, D, K, polyphenols, co-enzyme Q10, phosphatidylcholine).
  • Testing of the content of preservatives and PAH (polycyclic aromatic hydrocarbons).
  • Viscosity tests.
  • Testing particle-size distribution and zeta potential.
  • Developing analytical methods using HPLC, together with method validation.
  • Planning and carrying out stability tests to confirm the compliance of the product with the specification in accordance with ICH or ASTM guidelines (for medical devices).

 

ADME tests (adsorption, distribution, metabolism, excretion)

ADME in-vitro and ex-vivo tests are carried out at the initial stage of development of medicinal products (pre-clinical tests) and can be very useful in tests of cosmetics or dietary supplements. Synthos CARE offers a range of bioavailability tests to determine, for example, the permeability of active substances into the skin, transdermal penetration, or the bioavailability of substances administered orally.
 

Synthos CARE carries out these and other tests:

  • Analysing the kinetics of the penetration of active substances into the skin using Franz cells, for which we use artificial skin, pig skin, and human skin, as models.
  • Parallel Artificial Membrane Permeability Assays (PAMPA) also help to determine the passive absorption and the bio-availability profile of active substances. The assay allows the determining of the initial absorption of active substances after oral administration (light substances, dietary supplements) and after epidermal administration of the so-called SKIN-PAMPA model.
  • The stability of substances in the S9 fraction – an ADME-supportive assay to determine the stability of active substances in the presence of the S9 fraction, which is a mixture of cytosol and microsomes, which metabolise active substances.
  • Microsomal stability – an assay to determine the stability of active substances in the presence of hepatic microsomes.

Custom- made formulations:
We offer assistance in the development of innovative formulas based on lipid nanocarriers (liposomes, SLN, NLC, nanoemulsions, SEDDS) dedicated to the pharmaceutical, cosmetic or food industry.
The services we offer allow us to solve problems with active substances which have low solubility, low stability or low bioavailability. The developed formations are tested in accordance with the QbD (Quality by Design) and ICH guidelines.

Process scalling
We offer the possibility of scaling the production of formulations based on lipid nanocarriers by transferring solutions developed in the laboratory on a semi-technical and technical scale. Thanks to the extensive equipment base, we are able to perform up-scaling starting from very small series and ending with a series of 50 kg to 500 kg.

Liposomes for research purposes
We offer liposomes for research purposes both empty with a very wide lipid composition, fluorescently labeled liposomes, and finally liposomes containing drugs such as doxorubicin (Doxil analog).

 

Brochures and TDS are available exclusively at customers’ request through e-mail.